Reducing the frequency of Autoimmune adverse events in the treatment of Multiple sclerosis with alemtuzumab using B-celL dEpletion (RAMBLE): a phase II, randomised, placebo-controlled clinical trial
To reduce the occurrence of autoimmune adverse events from the treatment of multiple sclerosis (MS) with alemtuzumab through the subsequent targeted use of rituximab. The hypothesis to be tested is that rituximab therapy following alemtuzumab treatment for MS will reduce the frequency of autoimmune adverse events. If this strategy proves to be safe and is […]
An investigation of a novel mechanism of obstructive sleep apnoea (OSA) in people with Multiple Sclerosis (MS)
Multiple sclerosis (MS) and obstructive sleep apnoea co-occur frequently with shared symptoms such as fatigue, depression and cognitive impairment which when together may be more severe and difficult to manage. The mechanisms for the high prevalence of sleep apnoea in people with MS are unclear. Understanding the causes of sleep apnoea in people with MS […]
Assessing Lower Limb Strength and Walking Ability in Individuals with Multiple Sclerosis
The research study aims to investigate strength in the lower limb and its association with walking ability. In addition, other factors related to Multiple Sclerosis (MS) that may affect walking, including spasticity, balance, leg sensation and contractures in the ankle, will be assessed. We hope to use the information we get from this research study […]
Exploring the food journey to inform guidance for persons living with Multiple Sclerosis
Interviews using open-ended questioning to be conducted online (zoom/webex/microsoft teams) for approximately 30-45 minutes. The purpose of this research is to explore the topic of food with individual’s diagnosed with multiple sclerosis (MS) and investigate what factors might influence their experience with food. This project will add to the research to help identify factors that […]
Light Therapy for Fatigue and Daytime Sleepiness in Multiple Sclerosis
Fatigue and excessive daytime sleepiness are common complaints in individuals living with multiple sclerosis (MS). Fatigue and excessive daytime sleepiness are associated with the emergence and exacerbation of cognitive, motor and mood disturbances and over time lead to impaired rehabilitation outcomes, a decline in the capacity to perform daily activities and reduced quality of life. […]
ACEMS: Aspirin, Cooling and Exercise in Multiple Sclerosis
This study aims to observe the effectiveness of a practical cooling strategy (cold water spray bottle skin cooling) in reducing heat-related fatigue in hot conditions for people with MS. Participants will complete 5 sessions in total: • 3 practice sessions (1.5hr each): two cycling, handgrip & balance sessions in room temperature conditions, and one in […]
Testing a new ice vest that could help people experiencing Multiple Sclerosis exercise
To investigate the acute effect of the UnderCool 2.0 cooling vest during high-intensity exercise in a heat sensitive MS population on; i) body temperatures and sweating, ii) feelings of exertion and hotness, iii) MS symptoms that are aggravated by heat, and iv) Concealability, comfort and functionality. With a controlled, cross-over design, 20 participants diagnosed with […]
SARS-CoV-2 antibody after COVID-19 vaccination in patients with multiple sclerosis
COVID-19 vaccines are now being rolled out. Many people living with MS are treated with drugs that affect their immune system, and there is not a lot of specific data relating to the administration of the COVID-19 vaccines to a person with MS who is treated for their disease. This is a multi-center study to […]
An Open Label Observational Study of Safety and Efficacy of a Pharmaceutical grade Cannabis Medicine (MediCabilis™-CBD extract Oil) in Patients undergoing Medicinal Cannabis Therapy for Different Indications
This study is a nation-wide observational study aiming to assess the safety, tolerability and efficacy of a non-intoxicating cannabidiol-dominant medicinal cannabis in managing chronic conditions that haven’t responded well to traditional treatment options, including multiple sclerosis. Patients who are prescribed Bod medicinal cannabis and meet the eligibility criteria will be able to participate in this […]
Project SCORE: Music and Walking for Neurology
Walking is a great form of exercise and in this study we are interested in the effect of walking to music in people with neurological health conditions. The randomised controlled study is a feasibility study meaning that we will focus on the processes of walking to music in comparison to walking with no music. We […]