Clinical Trials

Magnetic brain stimulation for multiple sclerosis trial

Type of Study/Intervention


Recruitment Status

Not yet recruiting

Form of MS

Relapsing remitting MS, Secondary progressive MS

Brief summary

Transcranial magnetic stimulation is a safe and well proven technique used to treat a number of psychiatric and neurological disorders. It has never been trialled in MS. We have demonstrated that TMS may have an effect on the ability of brain cells to replenish the myelin sheath (the insulation surrounding nerve cells) which may thus help multiple sclerosis lesions to heal. This data is from animals and cell culture and has not been shown in humans. This study is a safety/tolerability study of TMS in humans to determine whether wee can give TMS to people with MS with acceptable tolerability and safety. We will also collect preliminary data on the effects of TMS on people with MS and their MRI scans.

Inclusion criteria

– Definite MS
– Aged 18-65
– Either secondary progressive or relapsing remitting MS
– Able to have an MRI scan
– EDSS < /= to 6 - At least moderate cerebral MS plaque load as determined by trial neurologist - Able to give informed consent - Not pregnant - Not on anti-epileptic and antipsychotic medications - No metallic devices or foreign bodies

Exclusion criteria

– Other types of MS
– Pregnancy
– Unable to have an MRI scan
– Unable to provide consent.
– On anti-epileptic or antipsychotic medications
– History of other concomitant neurological disorder that may complicate assessment e.g. Parkinson’s, Epilepsy, Migraine or Stroke

Anticipated start date


Recruitment contacts

Prof Bruce Taylor: [email protected]

T: 03 62267700



Further details

Full details of the trial can be found on the ANZCTR clinical trials database: ACTRN12619001196134

Ethics approval


Last updated


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