Project BASE: Changing Behaviour towards Aerobic and Resistance Exercise

Engaging in physical activity is beneficial to the wellbeing of people with MS. The aim of the study is to assess the feasibility of a study designed to involve people with MS in an exercise program. You’ll take part in a four-month at home exercise program, guided by our team of BASE physiotherapists, occupational therapists […]

Social connectedness and long-term health conditions

This is a qualitative research study that aims to gain a better understanding of the experiences of loneliness of people living with long-term health conditions (such as MS). We have already finalised recruitment for participants living with long-term health conditions and are now seeking health- and community-care professionals who provide care and support for people […]

The Wellbeing Neuro Course: A Randomised Controlled Trial of an Online Treatment Program for Adults with Multiple Sclerosis

Mental health (e.g., anxiety, depression) and functional difficulties (e.g., cognitive problems) are highly comorbid in people with Multiple Sclerosis (MS). However, access to effective psychological treatments are limited. People with MS face many barriers (e.g., costs, limited trained clinicians, mobility issues) accessing effective psychological care. The Wellbeing Neuro Course offers an innovative solution to these […]

Reducing the frequency of Autoimmune adverse events in the treatment of Multiple sclerosis with alemtuzumab using B-celL dEpletion (RAMBLE): a phase II, randomised, placebo-controlled clinical trial

To reduce the occurrence of autoimmune adverse events from the treatment of multiple sclerosis (MS) with alemtuzumab through the subsequent targeted use of rituximab. The hypothesis to be tested is that rituximab therapy following alemtuzumab treatment for MS will reduce the frequency of autoimmune adverse events. If this strategy proves to be safe and is […]

MINDS-MS: Improving the detection and treatment of depression in multiple sclerosis

This research will assess knowledge, current practices, barriers and required supports to improve the detection and treatment of depression in people with MS. It assesses this from the perspective of what people with MS have experienced and believe will assist to improve healthcare support. This information will be used to develop tools, resources and guidelines […]

Assessing Lower Limb Strength and Walking Ability in Individuals with Multiple Sclerosis

The research study aims to investigate strength in the lower limb and its association with walking ability. In addition, other factors related to Multiple Sclerosis (MS) that may affect walking, including spasticity, balance, leg sensation and contractures in the ankle, will be assessed. We hope to use the information we get from this research study […]

A Phase 3, Randomized, Double-Blind, Efficacy and Safety Study Comparing SAR442168 To Placebo In Participants With Primary Progressive Multiple Sclerosis (PERSEUS)

SAR442168 is being developed for the indication of treatment of patients with MS. This study is designed to collect evidence of efficacy and safety of the drug. The goal of this Phase 3 clinical trial is to demonstrate the efficacy and safety of SAR442168 compared to placebo in participants with primary progressive multiple sclerosis (PPMS). […]