Project BASE: Changing Behaviour towards Aerobic and Resistance Exercise

Engaging in physical activity is beneficial to the wellbeing of people with MS. The aim of the study is to assess the feasibility of a study designed to involve people with MS in an exercise program. You’ll take part in a four-month at home exercise program, guided by our team of BASE physiotherapists, occupational therapists […]

Social connectedness and long-term health conditions

This is a qualitative research study that aims to gain a better understanding of the experiences of loneliness of people living with long-term health conditions (such as MS). We have already finalised recruitment for participants living with long-term health conditions and are now seeking health- and community-care professionals who provide care and support for people […]

Reducing the frequency of Autoimmune adverse events in the treatment of Multiple sclerosis with alemtuzumab using B-celL dEpletion (RAMBLE): a phase II, randomised, placebo-controlled clinical trial

To reduce the occurrence of autoimmune adverse events from the treatment of multiple sclerosis (MS) with alemtuzumab through the subsequent targeted use of rituximab. The hypothesis to be tested is that rituximab therapy following alemtuzumab treatment for MS will reduce the frequency of autoimmune adverse events. If this strategy proves to be safe and is […]

Assessing Lower Limb Strength and Walking Ability in Individuals with Multiple Sclerosis

The research study aims to investigate strength in the lower limb and its association with walking ability. In addition, other factors related to Multiple Sclerosis (MS) that may affect walking, including spasticity, balance, leg sensation and contractures in the ankle, will be assessed. We hope to use the information we get from this research study […]

Exploring the food journey to inform guidance for persons living with Multiple Sclerosis

Interviews using open-ended questioning to be conducted online (zoom/webex/microsoft teams) for approximately 30-45 minutes. The purpose of this research is to explore the topic of food with individual’s diagnosed with multiple sclerosis (MS) and investigate what factors might influence their experience with food. This project will add to the research to help identify factors that […]

Light Therapy for Fatigue and Daytime Sleepiness in Multiple Sclerosis

Fatigue and excessive daytime sleepiness are common complaints in individuals living with multiple sclerosis (MS). Fatigue and excessive daytime sleepiness are associated with the emergence and exacerbation of cognitive, motor and mood disturbances and over time lead to impaired rehabilitation outcomes, a decline in the capacity to perform daily activities and reduced quality of life. […]

ACEMS: Aspirin, Cooling and Exercise in Multiple Sclerosis

This study aims to observe the effectiveness of a practical cooling strategy (cold water spray bottle skin cooling) in reducing heat-related fatigue in hot conditions for people with MS. Participants will complete 5 sessions in total: • 3 practice sessions (1.5hr each): two cycling, handgrip & balance sessions in room temperature conditions, and one in […]