Project BASE: Changing Behaviour towards Aerobic and Resistance Exercise

Engaging in physical activity is beneficial to the wellbeing of people with MS. The aim of the study is to assess the feasibility of a study designed to involve people with MS in an exercise program. You’ll take part in a four-month at home exercise program, guided by our team of BASE physiotherapists, occupational therapists […]

A study to investigate the feasibility of smartphone-based self-monitoring to characterise cognitive and neurological impairment in participants with multiple sclerosis

This is a commercially sponsored study. F. Hoffman La Roche Ltd is the sponsor and owns the Floodlight MS app. Multiple sclerosis (MS) is a chronic (long-lasting), inflammatory, demyelinating (causing damage to the myelin sheath (protective covering) surrounding nerve fibers in the brain), and degenerative disease (characterized by progressive deterioration and loss of function) of […]

Social connectedness and long-term health conditions

This is a qualitative research study that aims to gain a better understanding of the experiences of loneliness of people living with long-term health conditions (such as MS). We have already finalised recruitment for participants living with long-term health conditions and are now seeking health- and community-care professionals who provide care and support for people […]

An early feasibility study of the safety of an endovascular Motor Neuroprosthesis (MNP) in participants with severe upper limb dysfunction

The Synchron Motor Neuroprosthesis (MNP) is intended to be used in subjects with severe upper limb motor impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning motor cortex. The purpose of this research is to evaluate safety and feasibility. The MNP is a type of implantable brain computer interface which bypasses dysfunctional motor […]

The Wellbeing Neuro Course: A Randomised Controlled Trial of an Online Treatment Program for Adults with Multiple Sclerosis

Mental health (e.g., anxiety, depression) and functional difficulties (e.g., cognitive problems) are highly comorbid in people with Multiple Sclerosis (MS). However, access to effective psychological treatments are limited. People with MS face many barriers (e.g., costs, limited trained clinicians, mobility issues) accessing effective psychological care. The Wellbeing Neuro Course offers an innovative solution to these […]

Reducing the frequency of Autoimmune adverse events in the treatment of Multiple sclerosis with alemtuzumab using B-celL dEpletion (RAMBLE): a phase II, randomised, placebo-controlled clinical trial

To reduce the occurrence of autoimmune adverse events from the treatment of multiple sclerosis (MS) with alemtuzumab through the subsequent targeted use of rituximab. The hypothesis to be tested is that rituximab therapy following alemtuzumab treatment for MS will reduce the frequency of autoimmune adverse events. If this strategy proves to be safe and is […]

An Open-label Study Evaluating Ofatumumab Treatment Effectiveness and PROs in Subjects With RMS Transitioning From Fumarate-based RMS Approved Therapies or Fingolimod to Ofatumumab (ARTIOS)

This is a single arm, prospective, multicentre and open-label, 96-week study to evaluate the treatment effectiveness of ofatumumab (OMB) in subjects with relapsing multiple sclerosis (RMS) transitioning from fumarate-based RMS approved therapies, such as dimethyl fumarate (DMF), diroximel fumarate (DRF), and monomethyl fumarate (MMF), or fingolimod due to breakthrough disease activity.